RAF Typhoon FGR4s have operated alongside French warplanes in a coordinated attack targeting an subterranean weapons facility in Syrian territory operated by the IS group, as stated by the UK's MoD.
The facility, located using surveillance, was thought to be storing arms and explosives, the statement said, and was positioned in mountains just north of Palmyra in Syria's central region.
"Our fighter planes used laser-guided Paveway IV weapons to hit a number of approach shafts leading to the facility... initial indications are that the target was engaged successfully," officials stated.
There was no sign of any civilian casualties in the attack on Saturday evening and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
IS - referred to as the so-called Islamic State - imposed militant control over parts of Iraq and Syria until 2019.
"This operation underscores British leadership, and determination to operate in unison with our partners, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the area," UK Defence Secretary the minister said.
British military aircraft have performed overwatch operations over Syria to "deter any attempted resurgence" of the group following its military defeat at the battle of Baghuz in the year 2019, the MoD reported.
"I extend gratitude to every member of our armed forces participating in this operation for their professionalism and their bravery," the Defence Secretary commented. "They were among thousands of British personnel stationed over Christmas and New Year. This mission, to eliminate dangerous terrorists who pose a risk to our way of life, demonstrates how British military are prepared to act, throughout the year, keeping Britain secure domestically and powerful internationally."
During December, the American forces conducted what it called a "major assault" against Daesh sites in the country, following an assault killed two American soldiers and a civilian linguist in Palmyra.
The U.N. says Daesh still maintains an estimated 5,000 to 7,000 fighters in both countries.